Anti-IFFO1

This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010], Protein function: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Nucleus . Nucleus, nucleoplasm . Nucleus inner membrane . Nucleus matrix . Mainly soluble, the remaining is localized in the nuclear matrix (PubMed:31548606). Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures (PubMed:31548606). .