Anti-IDH2 (R172H), monoclonal

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
NB-26084	100 µl		-	-	10 - 14 business days*		746.00€

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Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50%... more

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Product information "Anti-IDH2 (R172H), monoclonal"

Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations of Arg-172 in IDH2 to Cys, His, Leu or Ser abolish magnesium binding and the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R-2-hydroxyglutarate. Elevated levels of R-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.

Keywords:	Anti-FKBP, Anti-PPIase, Anti-FKBP12, Anti-CG11001, Anti-Rotamase, EC=5.2.1.8, Anti-Macrolide-binding protein, Anti-12 kDa FK506-binding protein, Anti-Peptidyl-prolyl cis-trans isomerase
Supplier:	NewEast Biosciences
Supplier-Nr:	26084

Properties

Application:	ELISA, WB, IF, IHC
Antibody Type:	Monoclonal
Conjugate:	No
Host:	Mouse
Species reactivity:	vertebrates
Immunogen:	synthetic peptide from the internal region of human IDH2 which includes the mutation of R172H
Format:	Purified