Anti-HtrA3 (Probable Serine Protease HTRA3, High-temperature Requirement Factor A3, Pregnancy-relate

HtrA3 belongs to the human high-temperature requirement factor A (HtrA) family. It is also called pregnancy-related serine protease. HtrA3 has two isoforms (long and short), which is produced by alternative splicing. Similar to HtrA1, HtrA3 binds to various TGF-beta proteins and inhibited the signaling of BMP-4, -2 and TGF-beta 1. HtrA3 does not inhibit signaling originated from a constitutively active BMP receptor, indicating that the inhibition occurred upstream of the cell surface receptor. Applications: Suitable for use in Western Blot and Immunocytochemistry/Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.