Anti-HTATSF1 / HIV Tat-specific factor 1, clone 25H56

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. HIV Tat-specific factor 1 antibody targets HIV Tat-specific factor 1, encoded by the HTATSF1 gene on chromosome 17q21.31. HIV Tat-specific factor 1 is a nuclear regulatory protein that functions at the intersection of transcription elongation and RNA processing. Although first identified for its role in supporting HIV-1 Tat-mediated transcription, HIV Tat-specific factor 1 is now recognized as a broader host factor that contributes to efficient gene expression in mammalian cells.Functionally, HIV Tat-specific factor 1 participates in regulation of RNA polymerase II elongation rather than transcription initiation. It associates with elongating transcription complexes and supports productive transcript synthesis across actively transcribed genes. In parallel, HIV Tat-specific factor 1 facilitates coordination between transcriptional elongation and RNA processing events, allowing efficient coupling of nascent RNA synthesis with downstream maturation steps. A HIV Tat-specific factor 1 antibody supports studies focused on transcriptional elongation dynamics and RNA metabolism.HIV Tat-specific factor 1 localizes predominantly to the nucleus, where it interacts with components of the transcription and splicing machinery. The protein contains arginine-serine-rich regions and additional interaction motifs characteristic of RNA regulatory factors, enabling binding to RNA and protein partners within elongation and spliceosomal complexes. Alternative splicing of HTATSF1 transcripts may generate isoforms that modulate these regulatory activities in a context-dependent manner.From a biological and disease-relevance perspective, accurate regulation of transcription elongation and RNA processing is essential for cellular homeostasis. Dysregulated activity of HIV Tat-specific factor 1 has been investigated in cancer, where aberrant transcriptional control contributes to altered gene expression programs. In viral infection models, HIV Tat-specific factor 1 remains relevant due to its ability to enhance Tat-dependent transcription, illustrating how host transcription factors can be co-opted to support viral replication.At the molecular level, HIV Tat-specific factor 1 functions as a regulatory protein rather than an enzyme, acting through dynamic protein-protein and protein-RNA interactions. Post-translational regulation and complex assembly state can influence its functional behavior and apparent migration in biochemical assays without altering the primary amino acid sequence. HIV Tat-specific factor 1 antibody reagents support research applications focused on transcription elongation, RNA processing, and host-virus interactions, with NSJ Bioreagents providing reagents intended for research use.