Anti-HSP70, clone YN02095r

HSP70, a member of the heat shock protein family, is associated with cell division, apoptosis, and tumorigenesis. Studies have found that the expression of HSP70 may be related to the occurrence, development and prognosis of tumors. HSP70 antibodies also directly inhibit apoptosis and have been shown to be involved in the protective effects against heat stress and cytotoxic drugs. HSP70 is upregulated in HCC and is often used in HCC studies together with Glypican-3. Protein function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. [The UniProt Consortium]