Anti-Hsp60 (HspD1)

Heat shock protein 60 (Hsp60), also known as heat shock protein family D member 1 (HspD1), is an approximately 60 kDa protein that functions as a molecular chaperone. It belongs to the type I subclass of chaperonins and is found in eubacteria, mitochondria, and chloroplasts where its expression is induced by stress. Hsp60 primarily exists as a heptameric ring that it is converted to a tetradecameric double-ring structure in the presence of ATP. Within mitochondria, it associates with its co-chaperone, Hsp10, to form a barrel-like structure and refold proteins that have been shuttled to the mitochondria in an ATP-dependent manner. Hsp60 also has extramitochondrial functions such as the production of proinflammatory cytokines in human leukocytes and activation of innate immune receptors. Hsp60 expression is increased in the serum and saliva of patients with type 2 diabetes mellitus and mutations in HSPD1 lead to neurodegenerative diseases. Cayman's Hsp60 (HspD1) Polyclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes Hsp60 (HspD1) at 60 kDa from human samples.Synonyms: 60 kDa Chaperonin, Chaperonin 60, Cpn60, Heat Shock Protein 60, Mitochondrial Matrix Protein P1, P60 Lymphocyte Protein. Immunogen: Human recombinant Hsp60 (HspD1). Formulation: (Request formulation change), 100 µg of protein A-purified antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, IHC, and WB. UniProt Accession #: P10809.