Anti-HSD17B1

Item number	Size	Manual	Delivery time	Price
E-AB-65790.60	60 µl	-	7 - 16 business days*	243.00€
E-AB-65790.120	120 µl	-	7 - 16 business days*	389.00€
E-AB-65790.200	200 µl	-	7 - 16 business days*	645.00€

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Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol... more

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Product information "Anti-HSD17B1"

Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy. Protein function: Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. [The UniProt Consortium]

Keywords:	Anti-E2DH, Anti-E17KSR, Anti-20-alpha-HSD, Anti-17-beta-HSD 1, Anti-Estradiol 17-beta-dehydrogenase 1, Anti-20 alpha-hydroxysteroid dehydrogenase, Anti-17-beta-hydroxysteroid dehydrogenase type 1, Anti-Placental 17-beta-hydroxysteroid dehydrogenase, HSD17
Supplier:	Elabscience
Supplier-Nr:	E-AB-65790

Properties

Application:	IHC, IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant fusion protein of human HSD17B1 (NP_000404.2).