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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
H7500-50C.100 | 100 µg | - | - |
3 - 19 business days* |
886.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Heparan sulfate is a highly sulfated polysaccharide that can be found on the cell surface and... more
Product information "Anti-HS3ST4 (Heparan Sulfate Glucosamine 3-O-sulfotransferase 4, Heparan Sulfate D-glucosaminyl 3-O-"
Heparan sulfate is a highly sulfated polysaccharide that can be found on the cell surface and within the extracellular matrix. It is typically covalently attached to the protein core of proteoglycans, such as syndecans and glypicans. Heparin, on the other hand, can be considered as a highly sulfated version of heparan sulfate that is predominantly found in mast cells. Both heparin and heparan sulfate contain disaccharide repeats of uronic acid and N-acetylglucosamine and are modified by the same sulfotransferases. The uronic acid residues can be sulfated at the 2-O position by heparan sulfate 2-O sulfotransferase (HS2ST). The N-acetylglucosamine residues can be sulfated at the N, 3-O, and 6-O positions by N-deacetylase/N-sulfotransferases (NDSTs), heparan sulfate 3-O sulfotransferases (HS3STs) and heparan sulfate 6-O sulfotransferases (HS6STs) respectively. There are seven HS3STs in the human genome. HS3ST4 and HS3ST2 are brain specific and may participate in HS-dependent neurobiologic events. HS3ST4 can generate tetrasulfated heparan sulfate disaccharide, the most highly sulfated sugar found in biological samples, and may have a role in assisting HSV-1 entry and spread. HS3ST4 is a Golgi resident type II membrane protein and has the longest proline rich stem region among all HS3STs. Applications: Suitable for use in Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 8-25ug/ml, Immunoprecipitation: 25ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-3OST4, Anti-HS3ST4, Anti-3-OST-4, Anti-h3-OST-4, EC=2.8.2.23, Anti-Heparan sulfate 3-O-sulfotransferase 4, Anti-Heparan sulfate glucosamine 3-O-sulfotransferase 4, Anti-Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4 |
Supplier: | United States Biological |
Supplier-Nr: | H7500-50C |
Properties
Application: | IHC, IP |
Antibody Type: | Monoclonal |
Clone: | 12K103 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa184-456 from human HS3ST4 expressed in CHO cell line. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K09678 | Matching products |
UniProt ID : | Q9Y661 | Matching products |
Gene ID | GeneID 9951 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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