Anti-HOMER3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG59206.50	50 µg		-	-	6 - 14 business days*		551.00€

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Protein function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic... more

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Product information "Anti-HOMER3"

Protein function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). [The UniProt Consortium]

Keywords:	Anti-Homer-3, Anti-Homer protein homolog 3
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG59206

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant protein corresponding to R282-A360 of Human HOMER3
MW:	40 kD
Format:	Antigen Affinity Purified