Anti-HNRNPK

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA007644.25	25 µl		-		7 - 10 business days*		300.00€
ATA-HPA007644.100	100 µl		-		7 - 10 business days*		421.00€

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Protein function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C)... more

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Product information "Anti-HNRNPK"

Protein function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%

Keywords:	Anti-TUNP, Anti-HNRPK, Anti-HNRNPK, Anti-hnRNP K, Anti-Heterogeneous nuclear ribonucleoprotein K, Anti-Transformation up-regulated nuclear protein
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA007644

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: TEQPEETFPN TETNGEFGKR PAEDMEEEQA FKRSRNTDEM VELRILLQSK NAGAVIGKGG KNIKALRTDY NASVS (ATA-APrEST71605)