Anti-hnRNP K

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG58845.100	100 µl		-	-	6 - 14 business days*		624.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C)... more

Close menu

Product information "Anti-hnRNP K"

Protein function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. [The UniProt Consortium]

Keywords:	Anti-TUNP, Anti-HNRPK, Anti-HNRNPK, Anti-hnRNP K, Anti-Heterogeneous nuclear ribonucleoprotein K, Anti-Transformation up-regulated nuclear protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG58845

Properties

Application:	ICC, IF, IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant fusion protein corresponding to aa. 1-280 of Human hnRNP K (NP_112552.1)
MW:	51 kD
Format:	Affinity Purified