Anti-HLA-DRB1 / Major histocompatibility complex class II DR beta 1 chain, clone MSVA-478R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Major histocompatibility complex class II DR beta 1 (HLA-DRB1) is a transmembrane glycoprotein encoded by the HLA-DRB1 gene that forms the beta chain of the HLA-DR antigen receptor complex. HLA-DRB1 Antibody for IHC is used to visualize the distribution of this antigen-presenting molecule within formalin-fixed, paraffin-embedded tissues by immunohistochemistry, enabling evaluation of immune cell populations and tissue immune activity directly within histologic sections.The HLA-DR complex is a heterodimer composed of an invariant alpha chain encoded by HLA-DRA and a polymorphic beta chain encoded primarily by HLA-DRB1. Together these proteins assemble into a cell surface receptor responsible for presenting processed peptide antigens to CD4-positive helper T lymphocytes. This antigen presentation pathway is central to adaptive immune activation, coordinating interactions between antigen-presenting cells and T lymphocytes. As a result, expression of HLA-DR molecules is characteristic of professional antigen-presenting cells including B lymphocytes, macrophages, dendritic cells, and activated monocytes.Immunohistochemistry analysis of HLA-DRB1 provides valuable insight into immune cell distribution within tissues. In lymphoid organs such as tonsil, lymph node, and spleen, strong membranous staining is typically observed in B-cell zones, interfollicular antigen-presenting cells, and dendritic cell populations. Macrophages and other antigen-presenting cells within inflammatory infiltrates may also demonstrate prominent HLA-DR expression. This staining pattern allows pathologists and researchers to identify immune cell populations and evaluate immune responses within normal tissues, inflammatory lesions, and tumor microenvironments.HLA-DRB1 is highly polymorphic, with numerous allelic variants contributing to diversity in peptide binding and immune recognition across human populations. Variation in HLA-DRB1 has been associated with susceptibility to autoimmune diseases, transplant compatibility, and immune response variability. Because of these biological roles, antibodies targeting HLA-DRB1 are widely used in tissue-based immunohistochemistry studies examining immune infiltration, antigen-presenting cell localization, and immune activation in research and diagnostic settings.A recombinant rabbit monoclonal antibody such as clone MSVA-478R enables consistent immunohistochemical detection of HLA-DR beta chain expression in tissue sections. The resulting staining typically highlights membranous and cytoplasmic patterns in antigen-presenting immune cells within lymphoid tissues and immune infiltrates, supporting morphological assessment of immune cell distribution in histologic specimens.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.