Anti-HLA-DRA / Major histocompatibility complex class II DR alpha chain, clone MSVA-470R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Human leukocyte antigen DR alpha (HLA-DRA) is a major histocompatibility complex class II protein encoded by the HLA-DRA gene and forms the alpha chain of the HLA-DR antigen complex involved in antigen presentation. This molecule pairs with the HLA-DR beta chain to form a heterodimeric receptor that presents processed peptide antigens to CD4-positive T lymphocytes, playing a critical role in adaptive immune responses. HLA-DRA is therefore a central component of the MHC class II antigen presentation pathway and is highly expressed in professional antigen-presenting cells including B lymphocytes, dendritic cells, macrophages, and certain activated epithelial and immune cells.HLA-DRA Antibody Recombinant Rabbit MAb for IHC is used to detect expression of the HLA-DR alpha chain in formalin-fixed, paraffin-embedded tissues using immunohistochemistry. In normal tissues, HLA-DR alpha expression is typically observed in antigen-presenting cells within lymphoid organs and inflammatory microenvironments. Immunohistochemical staining often reveals membranous and cytoplasmic signal in B cells, macrophages, dendritic cells, and other immune cell populations involved in antigen processing and presentation. Detection of HLA-DRA by immunohistochemistry therefore provides valuable information about immune activation, antigen presentation, and inflammatory responses within tissue samples.The HLA-DR antigen is widely used as a marker of immune activation and antigen-presenting cell identity in both normal and diseased tissues. Because the HLA-DR complex consists of alpha and beta chains encoded by separate genes, antibodies targeting the alpha chain such as HLA-DRA antibody reagents allow specific evaluation of this component of the MHC class II receptor. Expression of HLA-DR alpha is tightly regulated and can be induced by cytokines such as interferon-gamma during immune responses. As a result, HLA-DRA expression frequently increases in inflammatory conditions, infection, autoimmune disease, and tumor microenvironments where immune cell infiltration occurs.In diagnostic and research pathology, HLA-DRA antibody staining is frequently used to evaluate immune cell populations and antigen presentation activity within tissues. The HLA-DR alpha chain is commonly detected in lymphoid tissues, sites of inflammation, and tumors with significant immune infiltration. Because HLA-DR expression reflects activation of antigen-presenting pathways, immunohistochemical analysis of HLA-DRA can help characterize immune microenvironments and assess interactions between immune cells and tumor cells. Clone MSVA-470R is a recombinant rabbit monoclonal antibody designed to recognize HLA-DRA and supports detection of the HLA-DR alpha chain in immunohistochemical staining applications.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.