Anti-HLA-DR (human) Immunoaffinity Resin (Clone L243)

HLA-DR is a MHC Class II cell surface receptor heterodimer composed of a 33-35 kDa alpha chain, a ~30 kDa beta chain, and a 10-30 amino acid ligand. When the heterodimer is fully combined on the cell surface of an antigen-presenting cell, such as macrophages, B cells, and dendritic cells, they present that ligand primarily to CD-4+ T cells. This presentation coupled with the T cell response can stimulate or suppress an antibody response to that ligand. HLR-DRs have been linked to a number of autoimmune disorders such as rheumatoid arthritis, lupus, and psoriasis as well as diabetes, hepatitis, and multiple sclerosis among a number of others. Cayman's HLA-DR (human) Immunoaffinity Resin (Clone L243) is designed for immunoprecipitation (IP) of HLA-DR from biological samples. IP is a portion of the MHC-II-associated peptide protemics (MAPPs) procedure used to identify immunogenic epitopes from pathogens, cancers, and biologic drugs. The HLA-DR immunoaffinity resin consists of Cayman's HLA-DR Monoclonal Antibody (Clone L243) (Cay21827) coupled to Sepharose.. SMILES: . InChi Code: . InChi Key: