Anti-HLA-B

In 1X PBS, pH 7.4, with 0.09% sodium azide. One of the key roles of the HLA-B protein (HLA class I histocompatibility antigen, B alpha chain) is to present fragments of proteins from foreign invaders to our immune cells, specifically T cells. This process, known as antigen presentation, allows our immune system to recognize and target these invaders for destruction. Without a properly functioning HLA-B protein, our immune system would struggle to effectively identify and combat threats. In addition to its role in immune response, HLA-B has also been linked to a variety of health conditions. Certain variations of the HLA-B gene have been associated with an increased risk of autoimmune diseases, such as rheumatoid arthritis and psoriasis. Understanding these genetic factors can help researchers develop personalized treatments that target the underlying causes of these conditions. Protein function: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:23209413, PubMed:25808313, PubMed:29531227, PubMed:9620674). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:18991276, PubMed:7743181). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:24600035, PubMed:29531227, PubMed:9620674). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227). [The UniProt Consortium]