Anti-Histone H2BK5Ac Rabbit (Clone RM455)

Histone H2B is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains a histone fold domain with a C-terminal alpha-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation. Acetylation of histone H2B at lysine 5 (H2BK5Ac) promotes the expression of genes associated with maintenance of the epithelial phenotype in trophoblast stem cells and stem-like claudin-low breast cancer cells. Histone H2BK5Ac is enriched at cardiac and renal promotors in diabetic rats. Cayman's Histone H2BK5Ac Rabbit Monoclonal Antibody (Clone RM455) can be used for ELISA, multiplex-based assay, and Western blot (WB) applications.. Cross reactivity: (+) H2BK5Ac: (-) Unmodified H2BK5, (-) H2B11Ac, (-) H2BK12Ac, (-) H2BK15Ac, (-) H2BK16Ac, (-) H2BK20Ac. (+) Human: (+) Vertebrates.. Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]