Anti-Histone H2B, monoclonal

Histone H2B is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Protein Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling [The Uniprot Consortium]