Anti-Histone H2B, clone 3C3

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-22086.20 20 µl -

7 - 16 business days*

72.00€
E-AB-22086.60 60 µl -

7 - 16 business days*

142.00€
E-AB-22086.120 120 µl -

7 - 16 business days*

238.00€
E-AB-22086.200 200 µl -

7 - 16 business days*

395.00€
 
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the... more
Product information "Anti-Histone H2B, clone 3C3"
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. HIST1H2BB (Histone Cluster 1 H2B Family Member B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN. Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]
Keywords: Anti-H2B/f, Anti-H2BFF, Anti-Histone H2B.f, Anti-Histone H2B.1, Anti-Histone H2B type 1-B, Anti-H2B-clustered histone 3, Histone H2B Monoclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-22086

Properties

Application: WB, IF
Antibody Type: Monoclonal
Clone: 3C3
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: Synthetic Peptide
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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