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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ARG56304.50 | 50 µl | - | - |
6 - 14 business days* |
551.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain... more
Product information "Anti-HIF1AN"
Protein function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. [The UniProt Consortium]
| Keywords: | Anti-FIH1, Anti-FIH-1, Anti-FIH-1, Anti-HIF1AN, Anti-Factor inhibiting HIF-1, Anti-Factor inhibiting HIF-1, Anti-Hypoxia-inducible factor 1-alpha inhibitor, Anti-Hypoxia-inducible factor 1-alpha inhibitor, Anti-Hypoxia-inducible factor asparagine hydroxyl |
| Supplier: | Arigo Biolaboratories |
| Supplier-Nr: | ARG56304 |
Properties
| Application: | ICC, IF, WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
| Immunogen: | Recombinant protein of Human HIF1AN |
| MW: | 40 kD |
| Format: | Antigen Affinity Purified |
Database Information
| KEGG ID : | K18055 | Matching products |
| UniProt ID : | Q9NWT6 | Matching products |
| Gene ID : | GeneID 55662 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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