Anti-Hif-1alpha hydroxy-Pro564

Anti-Hif-1alpha hydroxy-Pro564
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
100-401-A25 100 µl - -

1 - 9 business days

Protein function: Functions as a master transcriptional regulator of the adaptive response to... more
Product information "Anti-Hif-1alpha hydroxy-Pro564"
Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. [The UniProt Consortium]
Keywords: Anti-HIF1A, Anti-bHLHe78, Anti-BHLHE78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1, Anti-ARNT-interacting protein, Anti-PAS domain-containing protein 8, Anti-Hypoxia-inducible factor 1-alpha
Supplier: Rockland Immunochemicals
Supplier-Nr: 100-401-A25


Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Monkey, Mouse, Rat, Dog, Bovine, Xenopus)
Immunogen: synthetic peptide corresponding to a region surrounding the P564 of human HIF-1a

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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