Anti-HEC1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-770A-T	10 µl (10 µg)		-		2 - 8 business days*		178.00€
A300-770A	100 µl (100 µg)		-		2 - 8 business days*		630.00€

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Protein function: Acts as a component of the essential kinetochore- associated NDC80 complex,... more

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Product information "Anti-HEC1"

Protein function: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108). [The UniProt Consortium]

Keywords:	Anti-HEC, Anti-NDC80, Anti-HsHec1, Anti-Kinetochore protein Hec1, Anti-Kinetochore-associated protein 2, Anti-Kinetochore protein NDC80 homolog, Anti-Highly expressed in cancer protein, Anti-Retinoblastoma-associated protein HEC
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-770A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: rat, guinea pig, gorilla, chimpanzee)
Immunogen:	synthetic peptide. The epitope recognized by A300-770A-T maps to a region between residue 1 and 50 of human Highly Expressed in Cancer 1 (Kinetochore Associated 2) using the numbering given in entry NP_006092.1 (GeneID 10403).
Format:	Antigen Affinity Purified