Anti-HBS1L / HBS1-like protein

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. HBS1L antibody detects HBS1-like protein, encoded by the HBS1L gene on chromosome 6q23.3. HBS1L antibody is widely applied in studies of translation, mRNA surveillance, and hematopoiesis. HBS1L is a GTP-binding protein that functions in the no-go decay (NGD) pathway, a quality control mechanism that degrades mRNAs stalled during translation. It shares homology with translation elongation factors and interacts with the exosome complex and PELOTA to resolve stalled ribosomes. Expression is broadly detected across tissues, with particularly high levels in bone marrow and hematopoietic cells.Structurally, HBS1L is a ~70 kDa protein containing GTPase domains homologous to elongation factor 1a. These domains hydrolyze GTP to drive ribosome dissociation and recycling. A C-terminal domain mediates interactions with PELOTA and other decay machinery. Alternative splicing generates isoforms with distinct regulatory properties. Its domain organization reflects its role in linking translational control with RNA surveillance.Functionally, HBS1L participates in mRNA surveillance by recognizing stalled ribosomes and promoting their recycling. It collaborates with PELOTA to split ribosomes, freeing subunits for new rounds of translation. HBS1L also connects RNA quality control with hematopoietic differentiation, where it modulates globin gene expression and erythroid lineage decisions. Genome-wide association studies identify HBS1L variants as regulators of fetal hemoglobin levels. Researchers use HBS1L antibody to study mRNA decay, translation regulation, and blood cell development.Clinically, HBS1L is implicated in hematologic disorders and anemia. Genetic polymorphisms at the HBS1L-MYB intergenic region strongly influence fetal hemoglobin levels and modify disease severity in beta-thalassemia and sickle cell disease. These polymorphisms affect HBS1L expression and regulation, highlighting its clinical relevance. Dysregulated HBS1L expression also contributes to myelodysplastic syndromes and leukemias. NSJ Bioreagents supplies HBS1L antibody to support research in translation control, hematology, and RNA biology.Experimentally, HBS1L antibody is used in western blotting to detect the ~70 kDa protein, in immunohistochemistry to study bone marrow expression, and in immunofluorescence microscopy to examine cytoplasmic localization. Co-immunoprecipitation with HBS1L antibody identifies PELOTA and exosome complex partners involved in NGD.