Anti-HAND2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-61488.60 60 µl -

7 - 16 business days*

198.00€
E-AB-61488.120 120 µl -

7 - 16 business days*

317.00€
E-AB-61488.200 200 µl -

7 - 16 business days*

525.00€
 
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription... more
Product information "Anti-HAND2"
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. Protein function: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. [The UniProt Consortium]
Keywords: Anti-HAND2, Anti-dHAND, Anti-bHLHa26, Anti-BHLHA26, Anti-Class A basic helix-loop-helix protein 26, Anti-Heart- and neural crest derivatives-expressed protein 2, Anti-Deciduum, heart, HAND2 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-61488

Properties

Application: WB, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein of human HAND2

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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