Anti-GRP94

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Heat shock protein HSP 90-beta is a protein that in humans is encoded by the HSP90AB1 gene. Hsp90beta is mapped to chromosome 12q23.3. The function of Hsp90betaincludes assisting in protein folding, cell signaling, and tumor repression. This protein was first isolated by extracting proteins from stressed cells. These cells were stressed by heating, dehydrating or by other means, all of which caused the cell's proteins to begin to denature. Protein function: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) and secretion, the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). [The UniProt Consortium]