Anti-GRK6 [R07-3E4] Monoclonal Antibody -Knockout Validated

[KO] GRK6 Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro) [The Uniprot Consortium]