Anti-GRB10

Anti-GRB10
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-BN3 100 µg - -

6 - 10 business days*

684.00€
 
Anti-GRB10 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-GRB10"
Anti-GRB10 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least three isoforms of GRB10 are known to exist, this antibody will detect all three isoforms. Protein function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin- stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. [The UniProt Consortium]
Keywords: Anti-GRB10, Anti-GRBIR, Anti-GRB10 adapter protein, Anti-Growth factor receptor-bound protein 10, Anti-Insulin receptor-binding protein Grb-IR
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-BN3

Properties

Application: ELISA, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: 17 amino acid synthetic peptide near the C-terminus of human GRB10.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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