Anti-GPR99 (C-Term)

GPR99 is a G protein-coupled receptor (GPCR) that was originally identified as a purinergic receptor, P2Y15. However, it is activated by leukotriene E4 (LTE4, Cay-20410) in the low nanomolar range and by alpha-ketoglutarate in the high micromolar range. It is found in the CNS, kidney, epididymis, and other tissues in the mouse, as well as in human kidney, nasal turbinates, and lung, among other tissues. GPR99 knockout in mice prevents vascular leakage induced by LTE4 and epithelial cell mucin release in mouse nasal mucosa induced by LTE4 or A. alternata. In the kidney, under acid-base stress, it is involved with the regulation of carbonic acid and sodium chloride resorption through activation by alpha-ketoglutarate. GPR99 is also expressed in mouse retina, and axon growth is increased when it is activated by alpha-ketoglutarate in isolated mouse embryo retinal explants. Cayman's GPR99 (C-Term) Polyclonal Antibody can be used for Western blot and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminus of GPR99 from human samples.Synonyms: alpha-Ketoglutarate Receptor 1, GPR80, G Protein-Coupled Receptor 80, G Protein-Coupled Receptor 99, OXGR1, 2-Oxoglutarate Receptor 1, P2Y15, P2Y-like GPCR, P2Y-like Nucleotide Receptor, P2Y Purinoceptor 15. Immunogen: Synthetic peptide from the C-terminal region of human GPR99. MW: 38.3 kDa. Formulation: (Request formulation change), 500 µl of peptide affinity-purified antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: IHC and WB. UniProt Accession #: Q96P68.