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G protein-coupled receptor 6, also known asGPR6, is aproteinwhich in humans is encoded by theGPR6gene. GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate. GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth. Protein function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons. [The UniProt Consortium]
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