Anti-GPR31 (N-Term)

GPR31, also known as the 12(S)-HETE receptor (12-HETER), is a G protein-coupled receptor that is coupled to the Gi signal transduction pathway and activated by 12(S)-HETE (Cay-34570), a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). It is expressed by platelets and localizes to the plasma membrane and endoplasmic reticulum. siRNA knockdown of GPR31 inhibits 12(S)-HETE-induced tumor cell invasion in vitro, and Gpr31 knockdown in murine Hepa1-6 cells reduces tumorigenesis of those cells in a mouse model of hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury. It is overexpressed in prostate cancer tumors and positively correlated with tumor grade. Cayman's GPR31 (N-Term) Polyclonal Antibody can be used for ELISA, flow cytometry (FC), and immunofluorescence (IF) applications. The antibody recognizes the N-terminal region of GPR31 from human samples.Synonyms: 12-(S)-hydroxy-5,8,10,14-Eicosatetraenoic Acid Receptor, G Protein-Coupled Receptor 31, 12-HETER, 12(S)-HETE Receptor. Immunogen: A synthetic peptide from the N-terminal region of human GPR31. Formulation: (Request formulation change), 500 µl peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, FC, and IF. UniProt Accession #: O00270.