Anti-GPR161

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA015576.25	25 µl		-		7 - 10 business days*		369.00€
ATA-HPA015576.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Key negative regulator of Shh signaling, which promotes the processing of GLI3... more

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Product information "Anti-GPR161"

Protein function: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 93% and to rat: 92%

Keywords:	Anti-GPR161, Anti-G-protein coupled receptor RE2, Anti-G-protein coupled receptor 161
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA015576

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: MLLEDYTSDD NPPSHCTCPP KRRSSVTFED EVEQIKEAAK NSILHVKAEV HKSLDSYAAS LAKAIEAEAK INLFGEEALP GVLVTARTVP GGGFGGRRGS RTLVSQRLQL QSIEEGDVLA (ATA-APrEST72755)