Anti-GP6 / Glycoprotein VI

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. GP6 antibody detects Glycoprotein VI, a platelet membrane receptor that plays a key role in platelet activation and thrombus formation. GP6 functions as a receptor for collagen and signals through the immunoreceptor tyrosine-based activation motif (ITAM) pathway to promote platelet adhesion and aggregation following vascular injury. The GP6 antibody is widely used in hematology, cardiovascular, and hemostasis research to study platelet activation, coagulation, and thrombotic disease mechanisms.GP6 is encoded by the GP6 gene located on human chromosome 19q13.42. The protein is approximately 339 amino acids long and belongs to the immunoglobulin superfamily, featuring two extracellular Ig-like domains, a transmembrane region, and a short cytoplasmic tail that associates with the Fc receptor gamma chain (FcRgamma). This association is necessary for downstream signaling via the SYK tyrosine kinase and phospholipase C gamma 2 cascade.The GP6 antibody detects a 58 kilodalton band by western blot and shows strong membrane localization under flow cytometry and immunofluorescence microscopy. GP6 mediates platelet adhesion to exposed collagen fibers during vascular injury, triggering calcium mobilization, granule secretion, and integrin activation. This sequence of events leads to platelet aggregation and stabilization of the forming clot.Genetic deficiencies or polymorphisms in GP6 result in defective platelet-collagen interactions and mild bleeding disorders, while overactivation contributes to thrombotic conditions such as myocardial infarction and stroke. GP6 has also been identified as a therapeutic target for antiplatelet therapy because selective inhibition can prevent thrombosis without affecting normal hemostasis. Additionally, GP6 participates in inflammatory responses by modulating platelet-leukocyte interactions.Because of its central role in platelet physiology and vascular repair, GP6 provides an essential model for studying thrombosis, hemostasis, and inflammation. NSJ Bioreagents provides a validated GP6 antibody optimized for its applications, supporting research into platelet function, coagulation, and cardiovascular health.