Anti-gp100 (PMEL17), clone PMEL/783

Anti-gp100 (PMEL17), clone PMEL/783
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2856IHC-7ML 7 ml - -

3 - 10 business days

541.00€
 
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-gp100 (PMEL17), clone PMEL/783"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Cytotoxic T lymphocytes (CTL's) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein. Protein function: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. [The UniProt Consortium]
Keywords: Anti-PMEL, Anti-D12S53E, gp100 Antibody (PMEL17)
Supplier: NSJ Bioreagents
Supplier-Nr: V2856IHC-7ML

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: PMEL/783
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human SILV protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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