Anti-GnRH receptor, clone A9E4 (Monoclonal) [Mouse]

MON 8054 reacts with GnRH receptors in the anterior pituitary. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinising hormone (LH) as well as follicle-stimulating hormone (FSH). The receptor contains of seven hydrophobic transmembrane domains connected by hydrophillic extracellular, and intracellular loops characteristic of G-protein coupled receptors. Source: Mice were immunized with a BSA-conjugated peptide correspondin g to amino acids 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) of human GnRH receptor extracellular domain. Splenocytes were fused with SP2/0 mouse myeloma cells. Stability was established by subcloning four times. Protein function: Stimulates the secretion of gonadotropins, it stimulates the secretion of both luteinizing and follicle-stimulating hormones. [The UniProt Consortium]