Anti-GNE

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-63016.60 60 µl -

7 - 16 business days*

198.00€
E-AB-63016.120 120 µl -

7 - 16 business days*

317.00€
E-AB-63016.200 200 µl -

7 - 16 business days*

525.00€
 
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the... more
Product information "Anti-GNE"
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. Protein function: Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. [The UniProt Consortium]
Keywords: Anti-GNE, Anti-GLCNE, EC=2.7.1.60, Anti-ManAc kinase, EC=3.2.1.183, Anti-UDP-GlcNAc-2-epimerase, Anti-N-acetylmannosamine kinase, Anti-UDP-GlcNAc-2-epimerase/ManAc kinase, Anti-UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), GNE Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-63016

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein of human GNE

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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