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Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZgene. The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. GNAZ has been shown to interact with EYA2, RGS20 and RGS19. Protein function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. [The UniProt Consortium]
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