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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G8235-40A.100 | 100 µg | - | - |
3 - 19 business days* |
886.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Heparan sulfate proteoglycans (HSPGs) can be divided into general categories of cell-associated... more
Product information "Anti-Glypican 1 (Glypiated Proteoglycan 1)"
Heparan sulfate proteoglycans (HSPGs) can be divided into general categories of cell-associated forms, including syndecans, glypicans, and secreted extracellular matrix forms, such as perlecan. Glypicans contain six family members to date and are proteins bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor and involved in cellular adhesion and migration and function as accessory molecules for signaling receptors, (Filmus, 2008 & Gui, 2006). Current publications indicate the main function of membrane-attached glypicans is to regulate the signaling of Wnts, Hedgehogs, fibroblast growth factors and bone morphogenetic proteins (BMPs), (Filmus, 2008).Glypican-1 (GPC1) is over-expressed in human gliomas and appears to have a greater capability of promoting FGF-2 signaling in some gliomas versus HSPGs in normal astrocytes. Additional observations suggest that GPC1 can impact the growth of pancreatic cancer cells by attenuating tumor angiogenesis, (Whipple, 2008). Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5ug/ml, Immunohistochemistry (Paraffin): 1:50 detected strong cytoplasmic staining of tumor cells in formalin-fixed paraffin-embedded gangliobastoma tissue sample. There was negative staining of normal uninvolved cells., Optimal dilutions to be determined by the researcher. Positive Control: PC-12 cell lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-GPC1, Anti-Glypican-1, Anti-Secreted glypican-1 |
Supplier: | United States Biological |
Supplier-Nr: | G8235-40A |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | 9H239 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, rat |
Immunogen: | Full length recombinant human protein. Epitope: Full Length. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K08107 | Matching products |
UniProt ID : | P35052 | Matching products |
Gene ID | GeneID 2817 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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