Anti-GEMIN8

Anti-GEMIN8
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-64802.60 60 µl -

7 - 16 business days*

198.00€
E-AB-64802.120 120 µl -

7 - 16 business days*

317.00€
E-AB-64802.200 200 µl -

7 - 16 business days*

525.00€
 
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal... more
Product information "Anti-GEMIN8"
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. [The UniProt Consortium]
Keywords: Anti-GEMIN8, Anti-Gemin-8, Anti-FAM51A1, Anti-Protein FAM51A1, Anti-Gem-associated protein 8, GEMIN8 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-64802

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant protein of human GEMIN8

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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