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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30626 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interferons induce a large number of genes... more
Product information "Anti-GBP1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of two binding motifs rather than three. The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, respectively. All GBPs have a conserved N-terminal globular GTP-binding domain containing two consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene localizes to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B. Protein function: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. [The UniProt Consortium]
Keywords: | Anti-GBP1, Anti-GBP-1, Anti-HuGBP-1, Anti-GTP-binding protein 1, Anti-Guanylate-binding protein 1, Anti-Guanine nucleotide-binding protein 1, Anti-Interferon-induced guanylate-binding protein 1, GBP1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30626 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Amino acids 566-589 (QKESRIMKNEIQDLQTKMRRRKAC-human) were used as the immunogen for this GBP1 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K20899 | Matching products |
UniProt ID : | P32455 | Matching products |
Gene ID | GeneID 2633 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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