Anti-GAPex5

Anti-GAPex5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-115A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-115A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-115A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide... more
Product information "Anti-GAPex5"
Protein function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. [The UniProt Consortium]
Keywords: Anti-GAPVD1, Anti-GAPEX5, Anti-GAPex-5, Anti-Rab5-activating protein 6, Anti-GTPase-activating protein and VPS9 domain-containing protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-115A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, X. Laevis)
Immunogen: synthetic peptide. The epitope recognized by A302-115A-T maps to a region between residue 550 and 600 of human GTPase activating protein and VPS9 domains 1 using the numbering given in entry BAG10470.1 (GeneID 26130).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q14C86 | Find alternatives
Gene ID GeneID 26130 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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