Anti-FRG1 / FSHD region gene 1, clone 32F07

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. FRG1 antibody detects FSHD region gene 1 protein, encoded by the FRG1 gene. This protein is associated with RNA processing, pre-mRNA splicing, and actin cytoskeleton organization. FRG1 antibody provides researchers with a critical reagent for investigating muscular dystrophy, RNA metabolism, and nuclear architecture. Interest in FRG1 intensified because of its location within the genomic region associated with facioscapulohumeral muscular dystrophy (FSHD), a progressive muscle wasting disease.FSHD region gene 1 protein is expressed in both nuclear and cytoplasmic compartments. In the nucleus, it associates with splicing machinery and contributes to RNA maturation. Research using FRG1 antibody has demonstrated that overexpression of FRG1 alters splicing of muscle-specific transcripts, contributing to muscle pathology. In the cytoplasm, FRG1 interacts with actin filaments, influencing cytoskeletal organization and cell motility. These dual roles highlight its broad impact on cellular function.Overexpression of FRG1 has been shown to produce muscular dystrophy-like phenotypes in model organisms. Studies with FRG1 antibody have confirmed that excessive expression disrupts muscle development, leading to muscle weakness and degeneration. This evidence supports the hypothesis that misregulation of FRG1 contributes to FSHD pathology. Conversely, controlled levels of FRG1 appear necessary for normal muscle and vascular development, linking its regulation to tissue homeostasis.Beyond muscular dystrophy, FRG1 has been implicated in angiogenesis and vascular biology. Research with FRG1 antibody has revealed that it influences endothelial cell migration and capillary formation. Dysregulation of FRG1 may therefore contribute to vascular defects in addition to muscle abnormalities. This broadens the biological significance of FSHD region gene 1 protein to multiple tissues and disease processes.FRG1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies both endogenous and overexpressed FRG1, immunohistochemistry localizes it in muscle tissue, and immunofluorescence shows colocalization with nuclear speckles and actin filaments. These applications make FRG1 antibody indispensable for muscular dystrophy research.By supplying validated FRG1 antibody reagents, NSJ Bioreagents supports studies of RNA processing, muscle disease, and cytoskeletal organization. Detection of FSHD region gene 1 protein provides insight into how RNA and cytoskeletal regulation intersect in development and pathology.