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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3997-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V3997-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Reduced expression of... more
Product information "Anti-Frataxin / FXN, clone FDAX-1"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Reduced expression of frataxin is the cause of Friedreich's ataxia (FRDA), a lethal neurodegenerative disease. The reduction in frataxin gene expression may be attributable from either the silencing of transcription of the frataxin gene because of epigenetic modifications in the chromosomal entity or from the inability of splicing the expanded GAA repeats in the first intron of the pre-mRNA as seen in bacteria and human cells or both. The expansion of intronic trinucleotide repeat GAA results in Friedreich's ataxia. [Wiki] Protein function: Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+), the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization, however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. [The UniProt Consortium]
Keywords: | Anti-FXN, Anti-FRDA, EC=1.16.3.1, Frataxin Antibody / FXN |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3997 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | FDAX-1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Amino acids 57-210 from the human protein |
Format: | Purified |
Database Information
KEGG ID : | K19054 | Matching products |
UniProt ID : | Q16595 | Matching products |
Gene ID | GeneID 2395 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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