Anti-Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1, Fragile X Mental Retardation Syndrome-

Anti-Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1, Fragile X Mental Retardation Syndrome-
Item number Size Datasheet Manual SDS Delivery time Quantity Price
F6072-20B.100 100 µl - -

3 - 19 business days*

682.00€
 
Fragile X syndrome is a genetic disorder characterized by a spectrum of physical and behavioral... more
Product information "Anti-Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1, Fragile X Mental Retardation Syndrome-"
Fragile X syndrome is a genetic disorder characterized by a spectrum of physical and behavioral features and is a frequent form of inherited mental retardation (1). The X-linked FMRP (FMR-1) and its two autosomal homologs, FXR1 and FXR2, are polyribosome-associated RNA-binding proteins that are involved in the pathogenesis of fragile X syndrome (1-3). Each of the fragile X proteins can self-associate as well as form heteromers with the other two related proteins (3). FMRP can act as a translation regulator and is a component of RNAi effector complexes (RISC), suggesting a role in gene silencing (4). The Drosophila homolog of FMRP (dFMRP) associates with Argonaute2 (Ago2) and Dicer and can coimmunoprecipitate with miRNA and siRNA (5). These results suggest that fragile X syndrome is related to abnormal translation caused by defects in RNAi-related pathways. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-Fragile X mental retardation syndrome-related protein 1
Supplier: United States Biological
Supplier-Nr: F6072-20B

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, monkey, mouse, rat
Immunogen: Synthetic peptide corresponding to the sequence of human FXR1 protein (KLH- coupled).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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