Anti-FOXP1 (C-Term) Rabbit Monoclonal Antibody (RM402)

Forkhead box P1 (FOXP1) is a member of the FOX family of transcription factors and a transcriptional repressor with roles in cardiac valve morphogenesis, B and T cell development, monocyte differentiation, and lung development. It is composed of an N-terminal polyglutamine tract, a zinc finger domain, a leucine zipper, and a C-terminal forkhead domain. FoxP1 is ubiquitously expressed and localized to the nucleus where it binds to DNA to regulate transcription. Increased expression of FOXP1 is associated with poor prognosis in patients with diffuse large B cell lymphoma (DLBCL). Mutations in FOXP1 are associated with language impairment, speech delay, and grammar defects in patients with autism spectrum disorder. Cayman's FOXP1 (C-Term) Rabbit Monoclonal Antibody (RM402) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Forkhead Box P1, Glutamine-rich Factor 1, QRF1. Immunogen: Peptide from the C-terminal region of human FOXP1. Clone Designation: RM402. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) FOXP1.