Anti-FOXP1

Anti-FOXP1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-620A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-620A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-620A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with... more
Product information "Anti-FOXP1"
Protein function: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence, the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). [The UniProt Consortium]
Keywords: Anti-MFH, Anti-FOXP1, Anti-HSPC215, Anti-Forkhead box protein P1, Anti-Mac-1-regulated forkhead
Supplier: Bethyl Laboratories
Supplier-Nr: A302-620A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-620A-T maps to a region between residue 627 and 677 of human forkhead box P1 using the numbering given in entry NP_116071.2 (GeneID 27086).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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