Anti-FOXM1 / Forkhead box protein M1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. FOXM1 antibody detects Forkhead box protein M1, a transcription factor that regulates cell cycle progression, DNA replication, and mitotic gene expression. Encoded by the FOXM1 gene on chromosome 12p13.33, this nuclear protein belongs to the Forkhead family of transcription factors, characterized by a conserved winged-helix DNA-binding domain. FOXM1 functions as a key regulator of cell proliferation by activating genes required for G1/S and G2/M phase transitions, including cyclins, PLK1, and CDC25B.FOXM1 localizes to the nucleus during interphase and associates with condensed chromosomes during mitosis. Its activity is controlled by phosphorylation through CDKs and PLK1, which modulate DNA-binding and transcriptional activation. FOXM1 also contributes to chromatin remodeling and genomic stability by facilitating DNA repair and replication stress responses. It serves as an essential factor in tissue regeneration, stem cell renewal, and oncogenic transformation.The FOXM1 antibody is widely used in cancer, developmental, and cell cycle research to investigate proliferation control and transcriptional regulation. Western blot analysis detects a 90 kilodalton band corresponding to FOXM1, while immunofluorescence shows strong nuclear staining in proliferating cells. This antibody enables assessment of mitotic activity and transcriptional control mechanisms in both normal and cancerous tissues.Overexpression of FOXM1 is a hallmark of many human cancers, where it promotes tumor growth, angiogenesis, and metastasis through activation of cell cycle and invasion-related genes. Its inhibition is being explored as a therapeutic strategy for targeting rapidly dividing cells. The FOXM1 antibody provides a reliable tool for studying transcriptional regulation of proliferation and tumorigenesis. NSJ Bioreagents validates this antibody for its applications, ensuring accurate and reproducible detection for transcriptional and oncogenic research.