Anti-FOXC2 / Forkhead box protein C2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. FOXC2 antibody detects Forkhead box protein C2, a transcription factor belonging to the forkhead family characterized by a conserved DNA-binding forkhead domain. FOXC2 plays essential roles in embryonic development, angiogenesis, lymphangiogenesis, adipose differentiation, and epithelial-mesenchymal transition (EMT). It regulates transcriptional programs that control cell fate and morphogenesis in multiple tissues. The FOXC2 antibody is widely employed to investigate vascular development, cancer metastasis, and metabolic regulation, as FOXC2 activity is tightly linked to both physiological and pathological tissue remodeling.FOXC2 is encoded by the FOXC2 gene located on human chromosome 16q24.1. It binds to promoter regions of target genes containing the forkhead consensus sequence and activates transcription of genes involved in cell migration and morphogenesis. In the vascular system, FOXC2 controls differentiation of lymphatic endothelial cells and formation of lymphatic valves. Mutations in FOXC2 cause lymphedema-distichiasis syndrome, characterized by lymphatic dysfunction and abnormal eyelash growth.The FOXC2 antibody is frequently used in developmental and cancer research to detect protein expression in tissue sections and cultured cells. Western blot analysis typically reveals a 50?55 kDa nuclear protein, while immunohistochemistry demonstrates nuclear staining in endothelial and mesenchymal cells. In cancer biology, FOXC2 serves as a key regulator of EMT and is upregulated in aggressive tumors, where it promotes invasion, metastasis, and resistance to chemotherapy.FOXC2 also contributes to adipose tissue differentiation and energy homeostasis by regulating genes that determine brown adipocyte lineage. It functions in cooperation with transcription factors such as PPARgamma and PRDM16. Beyond developmental and metabolic functions, FOXC2 is implicated in cardiac valve formation and osteogenesis. NSJ Bioreagents provides a validated FOXC2 antibody suitable for western blot, immunohistochemistry, and chromatin studies, supporting advanced research into developmental genetics, vascular biology, and tumor progression.