Anti-FOXA1

Anti-FOXA1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-BG0 100 µg - -

6 - 10 business days*

684.00€
 
Anti-FOXA1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-FOXA1"
Anti-FOXA1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Multiple isoforms of FOXA1 exists as a result of alternative splicing event. Protein function: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate, FOXA1 and FOXA2 seem to have at least in part redundant roles. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription, required for ESR1 binding to the NKX2-1 promoter in breast cancer cells, binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis- acting regulatory regions of these genes. Involved in glucose homeostasis. [The UniProt Consortium]
Keywords: Anti-FOXA1, Anti-HNF3A, Anti-TCF-3A, Anti-HNF-3A, Anti-HNF-3-alpha, Anti-Transcription factor 3A, Anti-Forkhead box protein A1, Anti-Hepatocyte nuclear factor 3-alpha
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-BG0

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: 17 amino acid peptide near the internal region of human FOXA1.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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