Anti-FMO3 (Dimethylaniline oxidase 3, FMO II, FMO form 2, Hepatic flavin-containing monooxygenase 3)

FMO3(Flavin-containing Monooxygenase 3) is an enzyme that in humans is encoded by , the FMO3 gene. The mammalian flavin-containing monooxygenases (FMO) represent a multigene , family whose gene products are localized in the endoplasmic reticulum of many , tissues. The FMO3 gene contains 1 noncoding and 8 coding exons. The FMO3 gene is mapped on , 1q24.3. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver , and lung and in adult kidney and lung, and in much greater abundance in adult liver. By Western blot , analysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 , is the major fetal isoform and FMO3 is the major adult isoform. FMO3 was expressed at intermediate , levels until 11 years of age when a gender-independent increase in FMO3 expression was observed , during puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates , for FMO3 such as nicotine. FMO3 metabolizes a number of drugs, including amphetamine, clozapine, , deprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide. UniProt Number: P31513, Gene ID: FMO3, Applications: Suitable for use in Western Blot. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.