Anti-Filaggrin, clone SPM181

Anti-Filaggrin, clone SPM181
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3364SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Filaggrin (filament aggregating protein) is a... more
Product information "Anti-Filaggrin, clone SPM181"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolized from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21.Filaggrin is essential for the regulation of epidermal homeostasis. Within the stratum corneum, filaggrin monomers can become incorporated into the lipid envelope, which is responsible for the skin barrier function. Alternatively, these proteins can interact with keratin intermediate filaments. Filaggrin undergoes further processing in the upper stratum corneum to release free amino acids that assist in water retention. [Wiki] Protein function: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. [The UniProt Consortium]
Keywords: Anti-FLG, Anti-Filaggrin, Filaggrin Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3364SAF-100UG

Properties

Application: FC, IHC, IF
Antibody Type: Monoclonal
Clone: SPM181
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A recombinant human FLG protein was used as the immunogen for this Filaggrin antibody.
Format: Purified

Database Information

UniProt ID : P20930 | Find alternatives
Gene ID GeneID 2312 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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