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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES16461.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES16461.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain... more
Product information "Anti-FILA2"
The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015], Protein function: Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Cytoplasm . Cytoplasmic granule . In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1. .
Keywords: | Anti-IFPS, Anti-FLG2, Anti-FLG-2, Anti-Filaggrin-2, Anti-Ifapsoriasin, Anti-Intermediate filament-associated and psoriasis-susceptibility protein, FILA2 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES16461 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthesized peptide derived from human FILA2 AA range: 402-452 |
Format: | Purified |
Database Information
KEGG ID : | K10384 | Matching products |
UniProt ID : | Q5D862 | Matching products |
Gene ID | GeneID 388698 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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